The Douro region has two Special Protection Areas (SPAs) for birds: the Vale do Côa SPA and the Douro Internacional e Vale do Águeda SPA.
The following birds are symbols of the region: the Egyptian vulture, the black stork, the griffon vulture, the scops owl, the black wheatear, the red-billed chow, and the golden oriole.
Some critically endangered species can also be found in the region, such as:
Mammal species are also abundant in the region, some of them also endangered, such as: